BiLuo KunYuan
Pioneer in Multi-Omics Precision
Microbiota Transplantation
Product system
PRODUCT ECOSYSTEM
The Trilogy System: A Path to Restoring Life's Essence
Perceiving Time Through the Microcosm, Rebirth Through Order
Eastern wisdom teaches: “ Observe celestial patterns to discern the shifts of time.” the inner cosmos—with its own constellations and landscapes.
BiLuo KunYuan's diagnostics transcend mere data acquisition—they are a profound meditation on life's intrinsic rhythms.
Guided by science as our lens, we illuminate the cosmos of microbial order and chaos;
Steered by philosophy as our compass, we navigate the essence of aging and the the possibility of youth.
Here, age reversal evolves from abstraction into a charted course.
【Vision Beyond Sight: Full-Length 16S Sequencing】
INTESTINAL MICROBIOTA
GENE TESTING
Precision Microbiota Transplantation
Detection
Transplantation
Health
&
Wellness
PREPMT
Establishing a high-dimensional microbiota database, building a human-derived strain bank,
overcoming colonization resistance, investigating metabolic factors, and developing microbiome mapping analytics...
Leveraging premium strain platforms and cutting-edge detection technologies,
“Biluo Kunyuan” has constructed the Microbiome-Based Precision Life Revitalization System
Precision Microbiota Detection
Revealing microbial diversity, abundance,
and dysbiosis patterns to identify breaches
in life's biological order.
Precision Microbiota Transplantation
Reconstructing targeted microbial
communities to restore structural
stability in the gut ecosystem.
Precision-Customized Probiotic
Synbiotic Formulation
Harnessing microbial consortia cooperation
and prebiotic substrates to establish a
sustainable ecological system.
Ancient Chinese observed the heavens above and the earth below, believing all creation's growth,
decline, renewal, and cosmic order stem from two forces that mutually draw upon each other:
BiLuo (碧落): Referenced in Daoist texts as the supreme, crystalline celestial realm,
embodying the downward flow of vital essence that perpetuates life.
KunYuan (坤元): Originating from the Book of ZhouYi (The Kun Hexagram ),
representing the earth's nurturing virtue and primordial generative forces—the foundation sustaining all beings.
Millennia later, as precision medicine unlocks the gateway to the microscopic realm,
ancient wisdom finds resonance in the laboratory.
Where classical texts attribute life's essence to “BiLuo”,
modern science defines vitality through microbial activity;
Where ancient scrolls anchor existence in “KunYuan”,
contemporary research locates life's order within the Gut Microbiome.
At this convergence of philosophy and science in the laboratory,
we reveal the enduring answer to lasting youth...
The Rhythm of Day and Night · Harmony of Earth and SkyAs nature divides day and night,
so does the human body balance activity and rest. True wellness aligns with the rhythm of time.
Day · “BiLuo ShengFa”Morning formula: Scientifically calibrated prebiotics and high-potency probiotics awaken and nourish beneficial gut
flora like the first dawn light, setting a vibrant foundation for daily metabolism and barrier function.
Night · “KunYuan HanYang”Night formula: Leveraging the core mechanisms of Gut-X Axes,
it delivers cellular-level targeted nutrients to key axes—gut-brain,
gut-skin, gut-liver—during sleep’s golden repair window, achieving profound restoration in silence.
This dance of day and night—rising and storing—creates a perfect cycle of “regulation and repair,”
making wellness as natural as breathing, yet embodying the systemic wisdom of minimal effort, systemic impact.
Health & Wellness
PREPMT——Thoughtful PMT Sidekick
Full-length 16S rRNA technology comparison
16S rRNA Variable RegionFull-length 16S rRNAMetagenomeResolutionSweet Spot
| Technical Comparison | 16S rRNA Variable Region | Full-length 16S rRNA | Metagenome |
|---|
| Resolution | Genus-level
(Low Resolution) | Species/Strain-level
(High Resolution) | Species/Strain-level
High Resolution) |
|---|
| Functional Prediction | Indirect Functional Prediction | More Accurate Taxonomic Profiling | Direct Functional Analysis |
|---|
| Cost &Time | Low | Moderate
(Sweet Spot) | High |
|---|
| Long-term Tracking | Poor Reproducibility & Stability | High Stability & Strong Reproducibility | Prohibitive Cost,
Not Suitable |
|---|
Scientific Foundation: End-to-End Golden Standard
CLIA-Certified In-House Lab Ensuring Clinical-Grade QC;
Full-Length 16S rRNA Sequencing for Species-Level Resolution;
Patented Ambient-Temp Stabilizer Preserving Microbial
Viability at Source.。
Comparative study of 5 preservation methods demonstrates:
Maintains bacterial community stability for 6 months at 25°C;
Performance comparable to -80°C;
Superior fecal sample preservation vs conventional ambient methods.
Patent Pending: CN 2018105489648 Medical Device Registration: Class
I MD- Fujian XMDB 20200377
Yang, Luxi, et al. "Preservation of the Fecal Samples at Ambient
Temperaturefor Microbiota Analysis with a Cost-Effective and Reliable
Stabilizer EffeGut."Science of the Total Environment, vol. 741, 2020, p.
140423.DOI:10.1016/j.scitotenv.2020.140423.
Your Precision Longevity Blueprint
True youthfulness is the restoration of life's primordial
order.Primordial State Deviation Score
Precisely quantify microbiota deviation from its native
Skip the guesswork. We offer tiered solutions from dietary
tweaks to microbiota transplants.
Helping you rebuild the “Kunyuan” foundation, so that life,
through the restoration of order, regains its ceaseless vitality.
- 肠-内分泌轴
- 肠-心轴
- 肠-脑轴
- 肠-免疫轴
- 肠-肝轴
- 肠-骨轴
- 肠-肌轴
- 肠-皮肤轴
- 肠-肺轴
- 肠-肾轴
- 肠-生殖轴
- 肠-代谢轴
46分
The Rejuvenation Cycle
The Precision-to-Management Continuum
Personalized Nutrition & Lifestyle ModulationPrecision Synbiotic Formulation
The Pioneer
“Microbiota + Metabolites”
Multi-omics PMT
Matching Technology
The Rarity
12 Core Metabolite Matrices
Achieve 100%
Coverage of 12 “Gut-X Axes”
The Ultimate Quality
Unprecedented Viable Bacteria Count,
Premium Donor Sources,
Exceptional Diversity.
Setting New Industry Benchmarks
In-House Medical-Grade Quality Control;
Aiming for Finer Bacterial Strain Analysis;
Patented Protective Agent Preserves Microbiota Activity at Source
Through systematic screening of hundreds of materials and multi-dimensional validation, TreatGut's
fourth-generation protective agent ensures exceptional stability after long-term cryopreservation—viability
rate increases by 12.44%, maintains microbiota structure closer to its initial state, and effectively reduces
capsule deformation.
A Fecal Dissolution Formulation with Protective Effects on Gut Microbiota.
Chinese Invention Patent: CN114554123A
Personalized Multi-omics Precision Matching
(Identification of Core Functional Species)
Gut microbiota engages in bidirectional regulation with systemic organs through the “Gut-X Axes.”
Building on this cutting-edge framework, we systematically assess the functional impact of microbiota on
systemic organ systems via 12 key axes—including gut-brain, gut-skin, gut-heart, and gut-liver—enabling
comprehensive aging risk prediction from the gut to the whole body.
TreatGut's Data Center conducted multi-batch full-length 16S sequencing on three dosage forms of finished
products, screening for microbial species with: Detection rate ≥90%, Abundance ≥0.01%.
These findings were cross-validated against seven core beneficial species identified through metagenomic
analysis of raw microbiota samples. Ultimately, six species stably present in finished products were confirmed
as core functional species.
Explore the taxonomic
composition of samplesMining Potential
Beneficial BacteriaExplore the core genera positively
correlated with key metabolites
Innovative Dual-Layer Capsule
The inner layer contains highly active intestinal bacteria
obtained through standardized preparation processes enhanced
with deodorization technology and iterative extraction via In-House
Medical-Grade Quality Control.
High Quantity≥40,001billion viable bacteriaHigh Diversity≥1,200microbial speciesHigh Microbiota Score>95points
High-Functional Bacteria Core Six Beneficial Species ≥57 billion
Multi-dimensional regulation of Gut-X AxesFaecalibacterium prausnitzii
Bacteroides ovatus
Odoribacter splanchnicus
Phascolarctobacterium faecium
Akkermansia muciniphila
Bifidobacterium longumQuantified Harmful Substances Heavy metals: Non-detectable
“One-Item-One-Code” Premium Transparent Full-Chain SystemProduction:Preparation to
Quality ControlDetection:Guaranteed Technical
ParametersPackaging:Traceability
Code Identification
Gut-X axes core factors, metabolites and functional significance
| Gut-X Axes | Core Factor Nomenclature | Metabolites | Functional Significance |
|---|
| Gut-Brain Axis | Neuro-joy Factor | Dopamine, N-Acetylserotonin, 5-Methoxy-tryptamine, Dihydrobiopterin (BH2),
5-HTP, etc. | Gut microbiota participate in regulating mood, reward and sleep by producing or modulating these substances, serving as key messengers for neurotransmitter synthesis and the “gut-brain dialogue”. |
|---|
| Gut-Immune Axis | Immunobalance
Factor | Resolvin D1 (RVD1), Indole-3-Acetic Acid (IAA), etc. | They are core regulators that actively modulate inflammatory responses, promote inflammation resolution, and maintain immune equilibrium. |
|---|
| Gut-Metabolism Axis | Metabolic
Hub Factor | Glycocholic Acid (GCA), Glycodeoxycholic Acid (GDCA), Branched-Chain Amino Acids (BCAAs), etc. | The core power unit that drives energy metabolism cycles and regulates lipid digestion and metabolic signals. |
|---|
| Gut-Reproductive Axis | Driver Factor | Dopamine, 5-HTP, Norepinephrine, Sex Hormone Metabolites, etc. | The gut microbiota and its metabolites may indirectly influence the endocrine balance and function of the reproductive system by modulating systemic inflammatory levels, affecting the stress response of the hypothalamic-pituitary-gonadal (HPG) axis, and participating in the enterohepatic circulation of sex hormones. The production of certain neuroactive substances (e.g., serotonin precursors) in the gut may also exert potential effects on neural circuits regulating mood and stress through complex gut-brain communication. |
|---|
| Gut-Heart Axis | Cardiorhythm Factor | Norepinephrine | A key regulator of cardiovascular tone, heart rate, and stress responses, as well as a critical link between gut and cardiac functions. |
|---|
| Gut-Kidney Axis | Structural-filtering
Factor | Glycylproline Dipeptide (Gly-Pro) | The glycylproline dipeptide, as a key characteristic fragment in collagen metabolism, reflects and participates in the metabolism and repair of the renal basement membrane and extracellular matrix. It acts on the glomerular filtration barrier by maintaining its structural integrity to ensure precise renal filtration and reabsorption functions. It serves as a critical biomarker for assessing and supporting the health of renal microstructure and its self-repair capacity. |
|---|
| Gut-Liver Axis | Chol-signal Factor | Glycocholic Acid (GCA), Glycodeoxycholic Acid (GDCA) | As a core bile acid, it transmits the fundamental signaling from the intestines to the liver, regulating bile secretion, hepatenteric circulation, and metabolism. |
|---|
| Gut-Skin Axis | Dermo-Barrier
Factor | Phytosphingosine, Glycylproline Dipeptide | The core foundational substance responsible for establishing and maintaining skin barrier integrity, as well as participating in skin repair and hydration. |
|---|
| Gut-Lung Axis | Safeguard Factor | Indole-3-Acetic Acid (IAA), N-Acetylserotonin (NAS) | Gut-derived IAA and NAS act as important aryl hydrocarbon receptor ligands and antioxidant precursors, effectively balancing pulmonary immune responses and mitigating excessive inflammation. Concurrently, they protect delicate alveolar epithelium and respiratory mucosa by neutralizing free radicals and reducing oxidative stress. |
|---|
| Gut-Bone Axis | Osteo-Build Factor | Glycylproline Dipeptide | As a collagen-characteristic peptide, it provides essential amino acids for skeletal connective tissue repair and reconstruction. |
|---|
| Gut-Endocrine Axis | Endo-Balance Factor | Indole-3-Acetic Acid (IAA),
5-Hydroxy-L-Tryptophan (5-HTP) | Indirectly regulates appetite, glucose metabolism, and overall endocrine network balance via serotonin pathways. |
|---|
| Gut-Muscle Axis | Revitalizing Factor | Glycylproline Dipeptide | Supplies muscle energy and repairs connective tissues by participating in energy metabolism and providing collagen components. |
|---|
Exclusive Wellness Experience
Personalized LetterA bespoke missive crafted uniquely for you, distilling customized
revitalization philosophy into an elegant prelude to this journey.
Precision Formulation
Curated blend of high-colonization human-derived strains +
globally pioneering probiotics + functional botanical ingredients,
rigorously calibrated to ensure each strain and active compound
precisely matches individual gut needs.
Targeted Precision Biotherapeutics
Droplet Microfluidic Encapsulation
The strain Maintains 94.8% bacterial viability in gastric acid.
Ensures robust delivery of active strains to the gut.
Pure Formulation Protocol
Zero artificial fragrances/preservatives
Monthly dynamic formula renewal
Progressively optimized through phased refinement
Daytime RegimenNurturing Microbiota, Fortifying Foundations
Nurturing Earth, Cultivating GoldAll life begins in fertile soil.
Initial Month: We focus not on
possession but on cultivation.
- 100 billion CFU probiotics per bottle.
- TreatGut’s proprietary human-derived complex strain TGⅠ.
- Multi-matrix shield: Probiotics × Prebiotics × Functional Botanicals.
Converging Rain, Growing ForestForests arise from nourishing rains.
Second Month: We transcend
fragments to embrace flourishing.
- 400 billion CFU probiotics per bottle.
- TreatGut’s advanced human-derived complex strain TGⅡ.
- 42 active strains covering core edible genera—full-spectrum, high richness.
Steady Pace, Lasting VitalityEndurance lies in unwavering flow.
Final Month: We seek not replace-
ment but persistence.
- 100 billion CFU probiotics + TreatGut’s human-derived complex strain TGⅢ.
- Polyphenolic compounds.
- Macromolecular fibers × Functional Botanicals.
Nighttime ProtocolTargeted Repair
Quiet Resonance of Earth
Nourishing Essence of Earth
As nature rests, all beings return to their roots.
Through the long night, we chase no fleeting
glory—only precision along the Gut-X axes.
12 Gut-X AxesLeveraging the Gut-X axis mechanisms revealed
in iMeta, we achieve cellular-level targeted
repair during the golden hours of sleep.
Truly Personalized FormulationDynamically calibrated to individual health goals.
Supreme Quality ControlDedicated GMP production line,
rigorously meeting pharmaceutical standards.
ChangYi™ High-Fiber Postbiotics
“Before sowing seeds, learn tenderness toward the soil.”
We champion “Gradual Renewal.” True comfort should never come at the body's expense.
Optimal preparation doesn't erase the body’s canvas—it restores order within chaos. We gently clear the
debris, creating an ideal niche at a comfortable rhythm, quietly awaiting new microbiota.
- ≥8g dietary fiber per sachet.
- 100mg MetaTech™ Complex Lactobacillus Postbiotics
- 8 precision-selected prebiotic strains.
ShuYi™ Composite Effervescent Tablets
“True protection stems from rigorous adherence to physiological standards.”
The journey of microbiota should not be an ordeal—but a comfortable migration. We engineer a precision-built,
stable, and efficient colonization shield.
- Neutral Environment (pH 4.5–7.0): Rapid buffering technology neutralizes initial mild acidity, opening a “golden time window”
for microbiota to pass through gastric acid. - Na⁺:K⁺≈2.5:1: Precisely mimics intestinal ionic concentration—aligned with physiological fluid balance.
- Botanical Guardians: Tremella polysaccharide & Lion's Mane mushroom—gentle, plant-based protection.
- Clean Formula: No artificial flavors. No preservatives.
- MetaTech™ Postbiotics: Lacticaseibacillus rhamnosus TG021 & Lacticaseibacillus paracasei 3Q225
TG Thermo-Regulating Cup
“True protection stems from rigorous adherence to physiological standards.”
The journey of microbiota should not be an ordeal—but a comfortable migration. We engineer a
precision-built, stable, and efficient colonization shield.
- Smart Digital Display: Real-time temperature monitoring.
- Precision Warmth: 37°C constant incubation.
- Silent Stability: Non-slip silicone cushion for vibration damping.
- Leak-Proof Seal: Invertible design with airtight closure.
