Li, male, 54 years old, complained of "intermittent abdominal bloating and discomfort for more than 3 years." In September 2019, he developed mid-upper abdominal discomfort and bloating after eating, which lasted from minutes to hours. He was accompanied by fatigue and laziness in activities. He often suffered from abdominal discomfort that affected his night's rest. He was successively treated with Delexin, Mitra, traditional Chinese medicine, Kangfuxin Liquid, omeprazole, etc. Although the symptoms were relieved, they still recurred. Gastroscopy in July 2022: chronic atrophic gastritis, colonoscopy: no obvious abnormalities were found in the entire colon, and she was treated with miltreostem, domperidone, and denoxicin, but she still had upper abdominal discomfort, and she often feared that she was sick, had obvious fatigue, and was unable to perform some daily labor, so she was admitted to the hospital for further diagnosis and treatment. Since the onset of the disease, I have poor energy and sleep, sleeping 3-4 hours a day, normal urination, and dry stool, once every 2-3 days.Weight loss of about 10kg (height: 168cm; weight: 47.0Kg, BMI: 16.65, weight loss greater than 5% in the past three months).

·Diagnosis: severe malnutrition

·Treatment plan:Improve sleep, symptomatic, microbiota transplantation treatment

·The first course of microbiota transplantation:Intestinal surgery on July 14, 2022, July 17, and July 21 respectivelyMicrobiota transplantation treatment, plus hepatoprotective drugs

·Second course of microbiota transplantation:Intestinal microbiota transplantation treatment was performed on September 27, September 28, and September 29, 2022 respectively.

Transplant efficacy

• After the first course of microbiota transplantation, the patient's symptoms improved significantly, his sleep improved significantly, his food intake increased, he was willing to do some activities, and his weight dropped from the original level.48kg increased to 52kg.

• secondAfter the course of microbiota transplantation, the patient's general condition improved, with no obvious abdominal distension or pain, and he was able to engage in normal social work.

The relevant inspection changes are as follows:

• After microbiota transplantation treatment, blood routine related indicators such as white blood cells, red blood cells, hemoglobin, and platelets improved.

• Before microbiota transplantation, serum alanine helium transferase (ALT) and serum aspartate aminotransferase (AST) were elevated.

Albumin (ALB) was low. After microbiota transplantation and hepatoprotective drug treatment, ALT and AST dropped to normal, ALB returned to normal, and all indicators tended to be stable.

• After microbiota transplantation, the patient's body mass index (BMI) increased from 16.67 to 18.44, which became normal.

• After microbiota transplantation, the patient's gut microbiota test score improved from 31.8 points to 42.7 points, and improved from a third-degree imbalance to a second-degree imbalance.