Chronic constipation is a digestive system disorder with high clinical incidence, with an incidence rate of about 70% in the adult population, and the incidence rate has climbed to more than 90% in the elderly group over 60 years old, and is often accompanied by superimposed risks of underlying diseases. The core feature is persistent abnormal defecation, including less than 3 defecation times per week, dry and hard feces, labored defecation, or a feeling of incomplete defecation. Some patients are also complicated by intermittent abdominal pain and bloating.

Although chronic constipation is easily regarded as a "minor problem", long-term chronic constipation not only seriously reduces the quality of life, but may also induce colonic melanosis and intestinal mucosal damage. For patients with diabetes and cardiovascular disease, labored defecation may indirectly increase the risk of acute attacks of underlying diseases, and the clinical harm cannot be ignored.

However, conventional treatment often falls into the dilemma of "treating the symptoms but not the root cause" - most patients rely on laxatives for temporary defecation. Long-term use can easily lead to weakening of the intestinal motility, drug dependence, and even destruction of the balance of gut microbiota, forming a vicious cycle of "constipation - medication - flora imbalance - aggravation of constipation". When conventional solutions are difficult to break through, Precision Microbiota Transplantation, which starts from the roots of intestinal microecology, is providing new solutions for such patients, and 60-year-old Mr. Han is one of the beneficiaries.

The patient in this case is Mr. Han, a 60-year-old adult male. In the past 2 years, Mr. Han has had intermittent distension and pain in the right lower abdomen without obvious triggers, occasional nausea, and has been troubled by constipation for a long time. In order to relieve the symptoms, he took laxatives such as "Dahuang Runchang Pills", gastrointestinal motility regulators such as "Motilin", and even tried "Tramadol" painkillers and "cephalosporin" antibiotics, but he was still unable to control the condition.

One year ago, Mr. Han went to Beijing Hospital for treatment. After receiving treatment with "pinaverium bromide and Weilikang Granules", his symptoms were relieved for only one month before relapsing again. As of the time of consultation, Mr. Han not only had abdominal pain and distension, but also experienced decreased physical strength, poor appetite and poor sleep. In the past month, his weight had dropped by about 3kg, and his quality of life was seriously affected.

In addition, Mr. Han’s previous examination showed that he had multiple jejunal ulcers, colonic melanosis, postoperative changes in the rectum, bronchiectasis in the lower lobe of the left lung with infection, and other problems. His intestinal function had long been “overwhelmed.” The choice and effect of conventional treatment options were even more limited due to the superposition of multiple factors.

In order to seek further treatment, Mr. Han chose to use TreatGut Pharmaceutical Group’s gut microbiota detection technology to explore the cause of the disease from the microecological level. The test results showed that there was a third degree of imbalance in the gut microbiota, accompanied by diarrhea, constipation, and inflammatory bowel disease-related flora imbalance characteristics, and the overall level of beneficial bacteria in the intestine was low.——This is one of the core reasons that led to his long-term constipation, insufficient digestive tract motility, and ineffective conventional drug treatment.

Based on Mr. Han’s gut microbiota test results and clinical diagnosis, TreatGut Pharmaceutical Group developed a personalized Precision Microbiota Transplantation plan for him, using oral capsule transplantation:

On September 15, 2025, Mr. Han performed his first capsule transplant. On days 1-3 of the transplant, Mr. Han took 20 liquid live bacteria enteric-coated capsules orally every day;With the double guarantee of determining the effect of bacterial colonization and patient tolerance, the first transplantFor 4-5 days, Mr. Han took 30 liquid live bacteria enteric-coated capsules orally every day.

shortAfter 5 days of transplantation treatment, Mr. Han's intestinal function showed significant and sustainable improvement. Different from the "forced defecation" of laxative drugs, the improvement stems from the recovery of autonomous intestinal function:

Transplantation1 day: Mr. Han’s post-meal bloating completely disappeared, and the “post-meal bloating” symptom that had troubled him for many years was relieved for the first time;

Transplantation2 days: Mr. Han's post-meal abdominal distension no longer reappeared, he had voluntary bowel movements 4 times that day, his intestinal peristalsis ability was significantly improved, and he had no drug-induced irritation;

Transplantation3 days: Mr. Han passed soft stool once, and the stool properties returned to normal;

TransplantationDay 5: Mr. Han has regular bowel movements once a day, with completely normal bowel movements, and symptoms of abdominal pain, bloating and other discomfort have completely disappeared.

It is not difficult to see from Mr. Han’s case that TreatGutPharmaceutical GroupThe core advantage in the field of Precision Microbiota Transplantation is always to"Precision" is the core, which is different from the "symptomatic treatment" of conventional treatment:

AccurateDetectiongo first：Through gut microbiota detection technology, it can not only clarify the degree of bacterial flora imbalance, but also locate the type of imbalance, provide scientific basis for subsequent treatment, and avoid"Blind transplantation";

AccurateSolution customization：Based on the patient's age, underlying diseases, severity of illness, and flora test results, an appropriate transplant method and dose are formulated.。

Focus on root cause treatment：It does not rely on drugs to relieve symptoms in the short term, but supplements beneficial bacteria, regulates the homeostasis of gut microbiota, restores the intestinal peristalsis and digestive function, solves the root cause of chronic constipation and slow digestive tract motility, and avoids recurrence of the condition.

For patients who have long-term chronic constipation and are ineffective with conventional treatments, especially those with underlying diseases or intestinal lesions, Mr. Han’s case proves that Precision Microbiota Transplantation is not"Alternative plan" is an effective way to solve the problem from the root of intestinal microecology. The future, TreatGutPharmaceutical GroupWe will also continue to use precise microecological technology as the core to bring safer and more effective treatment options to more patients with digestive system diseases.