High blood pressure, high blood sugar, and high blood lipids, you must be aware of these "three highs." Eat delicious food and drink spicy food every day, eat big fish and meat every day, and now there is the fourth high - high uric acid.With the continuous development of society and economy, people's lifestyle and dietary structure have also changed. But this has also brought about some negative effects that cannot be ignored. The direct manifestation is that the incidence of metabolic diseases such as diabetes, hypertension, and obesity has increased significantly.hyperuricemiaalsoIt is one of them. The prevalence of hyperuricemia in adults in my country is about 14%, and it is developing younger.Hyperuricemia (HUA)It refers to the excessive production and/or under-excretion of uric acid in the body under normal eating conditions. If the fasting blood uric acid level is higher than 420 μmol/L in men and higher than 360 μmol/L in women twice on different days, it is called hyperuricemia. Uric acid is the terminal metabolite of purine compounds in humans. Purine metabolism disorders lead to hyperuricemia. The prevalence of hyperuricemia is affected by many factors, including genetics, gender, age, and lifestyle.Common manifestations and harms of hyperuricemia
There is a close correlation between hyperuricemia and gout, heart failure, kidney disease, hypertension, atherosclerosis, coronary heart disease, stroke, etc., and is a symptom of the above diseases.independent risk factors. Monitoring blood uric acid levels is crucial for early prevention and treatment of related diseases.Therefore, if you find that uric acid is elevated, even if there are no obvious symptoms, you must take it seriously!The relationship between gut microbiota and hyperuricemia
More and more studies also show thatgut microbiota disorders are closely related to elevated uric acid.The human gut harbors trillions of microorganisms that are critical to host health. Many evidences indicate that gut microbiota dysbiosis is inextricably linked to the occurrence of metabolic, immune, and neurological diseases. In addition, gut microbes can produce some small molecule metabolites that affect host metabolism, such as short-chain fatty acids, which are critical for regulating human health. gut microbiota has also become a target for early diagnosis and treatment of many diseases.in the human body,About 1/3 of uric acid is excreted through the intestines. When uric acid is secreted into the intestines, it is rapidly metabolized by intestinal microorganisms such as Escherichia coli, Clostridium, and Pseudomonas. The increase in uric acid in the blood circulation will affect the intestinal environment, causing changes in gut microbiota, and these changes will further lead to hyperuricemia.The composition of fecal microbiota in patients with gout and hyperuricemia is significantly different from that in the normal population.In patients with gout, the abundance of some bacteria, such as Bacteroides faecalis and Bacteroides xylanolyticum, was significantly increased, while the abundance of some bacteria was decreased, such as Faecalibacterium prowazekii and Bifidobacterium pseudomicron. Similarly, levels of Prevotella, Dehalobacterium, Ruminococcus, and Lactobacillus were also reduced in a rat model of hyperuricemia.When fecal bacteria from hyperuricemic mice were transplanted into normal mice via fecal transplantation, serum uric acid levels in the normal mice also increased. Therefore,gut microbiota is closely related to the occurrence of hyperuricemia and may become a new target for alleviating and treating hyperuricemia and related diseases.TreatGut classic case sharingPrecision Microbiota Transplantation Therapy
Mr. Q, male, 39 years old. During routine physical examination, it was found that blood uric acid had been elevated for more than 2 years without obvious symptoms. Suffering from irritable bowel syndrome and moderate gut microbiota imbalance. The frequency of bowel movements is 2-3 times/day. And the stool is not formed, and the Bristol stool classification score is 5.Symptoms:1. Hyperuricemia 2. Moderate gut microbiota imbalance 3. Irritable bowel syndromeMain transplant requirements:Found that blood uric acid has been elevated for more than 2 yearsFive-dimensional model positioning:metabolic systemClinically, the comprehensive gut microbiota test provided by TreatGut is used to determine whether the microecological environment in the patient's intestinal tract is imbalanced and the risk of various diseases is determined by analyzing the composition and structure of the bacterial flora. Based on basic information such as gut microbiota characteristics, age, gender, region, and past medical history, the donor-recipient matching model is analyzed to conduct donor-recipient matching. In the end, doctors combine the test results and clinical diagnosis for treatment, which will be carried out in August 2022.Precision Microbiota TransplantationA course of treatment, through3 oral capsulestransplant in the form. The test results of this patient before and after treatment are shown in the following tables:
Comparison of physical data before and after transplantation
As can be seen from the figure below, the patient's gut microbiota score before transplantation was 50.2, and after transplantation the score increased to 63.5. The patient's gut microbiota dropped from a moderate imbalance to a mild imbalance.
2. Diversity of gut microbiota
As can be seen from the figure below, the patient's gut microbiota diversity index increased from 338 to 352 after transplantation.After transplantationDiversity of gut microbiota increased.
3.Related disease risk indexAs can be seen from the figure below, the patient's risk index for some related diseases has decreased after transplantation.The metabolic syndrome risk index dropped from 81.94 to 65.17, from high risk to medium risk;Alzheimer's diseaserisk indexfrom 63.75dropped to 29.66, from medium risk to low risk;Irritable Bowel Syndrome Risk Indexby 81.6dropped to 63.03, downgrading from high risk to medium risk.
Comparison of physical condition before and after transplantation
It has been more than 2 years since my blood uric acid was found to be elevated, with no obvious symptoms. Suffering from irritable bowel syndrome, moderate gut microbiota imbalance, and bowel movements 2-3 times/day. And the stool is not formed, and the Bristol stool classification score is 5. There is nocturia.After the transplantation, the patient reported the following changes after follow-up visits by TreatGut health care professionals:
①The frequency, shape and color of bowel movements have improved: 1 time/day, formed, banana stool②Nocturia improved: Nocturia disappeared after transplantation③Sleep improvement: It is easier to feel sleepy when the time comes, the frequency of waking up in the middle of the night is reduced, and it is easier to fall asleep④ Appetite and taste improvement: Increased appetite, less craving for ice cream in summer⑤ Mental mood improvement: Even if you go to bed late, you will feel energetic the next day⑥Reproductive function improved: morning erection lasts longer
Precision Microbiota TransplantationIn China, microbiota transplantation has been used to treat diseases for more than 1,700 years. In 300-400 AD, Chinese medicine practitioner Ge Hong described in detail the use of fecal suspensions to treat serious illnesses such as food poisoning and severe diarrhea in his book "Emergency Prescriptions". In recent years, microbiota transplantation has been used in the treatment of more than 30 diseases at home and abroad.Precision Microbiota Transplantation(Precision Microbiota Transplantation, PMT) refers to passing the gut microbiota of healthy donors through an intelligent intestinal bacteria processing systemMade into suspension or capsule, adoptDonor-receptor matchingThe technology selects the optimal donor flora, transplants it into the patient's intestines, and rebuilds the normal functional gut microbiota to achieve the treatment of intestinal and extraintestinal diseases.
TreatGut defines Precision Microbiota Transplantation from the following aspects,
Leading the microbiota transplantation industry towards the 3.0 era.
