[Case Sharing 7] Surprise! Skin problems are also related to gut microbiota?

2022-12-29 19:00

#skinproblem

What is a rash?

A rash is a skin lesion. There are various manifestations ranging from simple changes in skin color to swelling or blisters on the skin surface. The rash is characterized by large and small red patches, sometimes itchy, sometimes not itchy. There are many types and causes of rashes, including macules, papules, roseola, maculopapular rash, urticaria, etc. Diagnosis needs to be based on different situations.

Rash is a type of skin problem.

Did you know?

Skin problems are often closely related to our gut,

gut microbiota also affects skin health!

The relationship between gut microbiota and skin

The skin and intestine are both active and complex immune and neuroendocrine organs harboring an extensive microbiota. Skin is the largest organ of the human body and serves as a physical barrier against invasion by microorganisms. The intestine is composed of trillions of microbial communities and is considered an organ closely related to the health and longevity of the host.

gut microbiota has both beneficial and adverse effects on the normal physiology and dynamic balance of the intestine and skin.

gut microbiota play three fundamental roles since birth: protection, maintenance of metabolism, and regulation of the immune system. Early in life, the gut microbiota plays a role in protecting the host from pathogens.

However,Changes in gut microbiota diversity can disrupt mucosal immune tolerance and subsequently affect skin health. Disruption of intestinal integrity and imbalance of microbial communities can have an impact on the overall homeostasis of the skin.ring.

How does gut microbiota affect skin health?

gut microbiota can influence skin health in three ways:

bacterial metabolites

There is a harmful bacterium called "Clostridium difficile", which can metabolize aromatic amino acids into benzene or cresol. The two can enter the blood and then accumulate in the skin, and cause the expression of skin keratin to decrease, which can subsequently affect epidermal differentiation and barrier disorders.

Gut bacteria themselves

In addition to the metabolic products that can enter the blood circulation, the intestinal bacteria themselves can also enter the body, which can have an impact on other organs of the body, including the skin.

immune response

Many allergic reactions occur on the surface of the skin, but people with dysbiosis in their gut microbiota are prone to immune system imbalance and are therefore prone to allergies. In other words, allergies and intestinal disorders are closely related.

Simply put, when the gut microbiota is out of balance, it will lead to the destruction of the intestinal barrier function, and some harmful toxins or bacteria can easily enter the bloodstream, leading to chronic inflammation, etc. In this way, the human body is easily affected by various chronic health problems, including skin problems such as acne.

TreatGut classic case sharing

Precision Microbiota Transplantation Therapy

Mr. Chai, male, 42 years old. I have been troubled by rashes in my daily life for 2-3 years. Small patches of red skin appeared on my left forearm, accompanied by itching, irregular shape, unclear borders, and local skin damage. The rash worsened in July 2021, and I took traditional Chinese medicine to treat it, but it recurred.

Name:Mr. Chai

Gender:male

Age:42 years old

Diagnosis:The rash comes back again and again.

Main transplant requirements:1. Improve intestinal microecology; 2. Assist in regulating skin rash.

Molecular Diagnostics-Donor-Recipient Matching

Clinically, the comprehensive gut microbiota test provided by TreatGut Health is used to determine whether the microecological environment in the patient's intestinal tract is unbalanced and the risk of various diseases is determined by analyzing the composition and structure of the bacterial flora. Based on basic information such as gut microbiota characteristics, age, gender, region, and health status, the donor-recipient matching model is analyzed to conduct donor-recipient matching. In the end, doctors combine the test results and clinical diagnosis for treatment, which will be carried out in December 2021.Precision Microbiota TransplantationFirst course of treatment, passed 3 timesoral capsuletransplant in the form. The test results of this patient before and after treatment are shown in the following tables:

After transplantation

PART 01

Comparison of physical data before and after transplantation

1. gut microbiota score

As can be seen from the figure below, the patient's gut microbiota score before transplantation was 39.7. After the first course of transplantation, the gut microbiota score was 50.2, and the patient's gut microbiota changed from a severe imbalance to a moderate imbalance.The imbalance has eased。

2. Diversity of bacterial flora

As can be seen from the picture below, the diversity of the patient's bacterial flora before transplantation was insufficient and low.Microbiota diversity returns to normal after transplantation。

PART 02

Comparison of physical condition before and after transplantation

Before transplantation:

The rash problem lasted for 2-3 years. Small patches of red skin appeared on the left forearm, accompanied by itching, irregular shape, unclear borders, and local skin damage.

After transplantation:

The rash symptoms were significantly reduced, the number of small red flakes was reduced, the color became lighter, and there was no skin damage. Great relief in overall skin condition.

Before transplantation After transplantation

Precision Microbiota Transplantation

In China, microbiota transplantation has been used to treat diseases for more than 1,700 years. In 300-400 AD, Chinese medicine practitioner Ge Hong described in detail the use of fecal suspensions to treat serious illnesses such as food poisoning and severe diarrhea in his book "Emergency Prescriptions". In recent years, microbiota transplantation has been used in the treatment of more than 30 diseases at home and abroad.

Precision Microbiota Transplantation(Precision Microbiota Transplantation, PMT) refers to passing the gut microbiota of healthy donors through an intelligent intestinal bacteria processing systemMade into suspension or capsule, adoptDonor-receptor matchingThe technology selects the optimal donor flora, transplants it into the patient's intestines, and rebuilds the normal functional gut microbiota to achieve the treatment of intestinal and extraintestinal diseases.

TreatGut defines Precision Microbiota Transplantation from the following aspects,

Leading the microbiota transplantation industry towards the 3.0 era.

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