2022-12-17 14:00
Sleep disorders are manifestations of abnormal sleep amounts and abnormal behaviors during sleep, as well as disturbances in the normal rhythmic alternation of sleep and wakefulness.
Abnormal amount of sleep:Such as insomnia or excessive sleep;
Abnormal behavior during sleep:Such as sleepwalking and nightmares;
Sleep and wake rhythm disorders:For example, the circadian rhythm is reversed, sleeping during the day and awake at night.
1. Abnormal amount of sleep
It can include the following two categories:
One category isExcessive amount of sleep, somnolence or lethargy, and narcolepsy caused by brain lesions.
Another category isInsomnia caused by insufficient sleep, characterized by difficulty falling asleep, light sleep, easy or early awakening, etc.; some diseases are also often accompanied by insomnia, such as neurasthenia, anxiety, depression, etc.
2. Paroxysmal abnormalities in sleep
Point toSome abnormal behaviors occur during sleep, such as somnambulism, sleep talking (talking in sleep), night terrors, nightmares (nightmares), teeth grinding, etc.
Sleep occupies an unshakable position in the immune response. There are many exquisite mechanisms behind this hyperlink, one of which is related to sleep's impact on gut microbiota. Studies have shown that sleep is related to intestinal health.
gut microbiota not only regulates emotions through the gut-brain axis, but also regulates sleep rhythms. This "highway" of two-way communication links the central nervous system and the enteric nervous system.
The influence of gut microbiota on sleep interacts bidirectionally through three completely different pathways:
◆Immune regulatory pathways◆
In this pathway, gut microbes influence mood through interactions with immune cells, thereby modulating cytokine species, cell dynamics response issues, and prostaglandin E2.
◆Neuroendocrine pathway◆
The intestine is the most important endocrine organ in the body, with more than 20 types of enteroendocrine cells. gut microbiota affects the hypothalamic-pituitary-adrenal axis (HPA) and central nervous system (CNS) by regulating the secretion of neurotransmitters such as cortisol, tryptophan, and serotonin.
◆Vagus Nerve Pathway◆
The enteric nervous system also plays a crucial role in the vagus nerve pathway. In this pathway, gut microbiota exert their influence through sensory neurons in the intestinal myenteric plexus.
Mr. Xiao, male, 36 years old. in daily lifeShort deep sleep time, hoping to improve sleep disorders through sleep conditioning through Precision Microbiota Transplantation (PMT).
Name:Mr. Xiao
Gender:male
Age:36 years old
Diagnosis:1. Hyperlipidemia 2. Mild gut microbiota imbalance 3. Sleep disorder
Main transplant requirements:sleep conditioning
Clinically, the comprehensive gut microbiota test provided by TreatGut Health is used to determine whether the microecological environment in the patient's intestinal tract is imbalanced and the risk of various diseases is determined by analyzing the composition and structure of the bacterial flora. Based on basic information such as gut microbiota characteristics, age, gender, region, and health status, the donor-recipient matching model is analyzed to conduct donor-recipient matching. In the end, doctors combine the test results and clinical diagnosis for treatment, which will be carried out in March 2022.Precision Microbiota TransplantationFirst course of treatment, passed 3 timesoral capsuletransplant in the form. The test results of this patient before and after treatment are shown in the following tables:
1. gut microbiota score
As can be seen from the figure below, the patient's gut microbiota score before transplantation was 65.7, and after transplantation it was 72.2. The gut microbiota scoreIncreased by 10% after transplantation。
2. Sleep data
Average sleep duration/deep sleep duration before transplantation: 4 hours and 5 minutes / 1 hour and 9 minutes
Average sleep duration/deep sleep duration after transplantation: 7 hours and 14 minutes / 2 hours and 0 minutes
It can be seen that after microbiota transplantation, the patientSleep duration and deep sleep duration have been greatly improved！
Before transplantation:Difficulty falling asleep, less sleep time, short deep sleep time at night, and still feeling tired and sleepy after getting up in the morning.
After transplantation:
1. Sleep: The time of deep sleep increases significantly, and you feel sleepy at night;
2. Weight: skeletal muscle increases, body fat rate decreases, and fat in the limbs and abdomen decreases;
3. Improved taste preference: Appetite becomes better;
4. The color of defecation is better: yellow banana stool.
Precision Microbiota Transplantation(Precision Microbiota Transplantation, PMT) refers to passing the gut microbiota of healthy donors through an intelligent intestinal bacteria processing systemMade into suspension or capsule, adoptDonor-receptor matchingThe technology selects the optimal donor flora, transplants it into the patient's intestines, and rebuilds the normal functional gut microbiota to achieve the treatment of intestinal and extraintestinal diseases.
TreatGut defines Precision Microbiota Transplantation from the following aspects,
Leading the microbiota transplantation industry towards the 3.0 era.
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